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Pyoderma gangrenosum is a rare, often destructive, neutrophilic dermatosis characterized by painful, necrotic superficial ulceration, central suppurative exudate and a peripheral undermined border. Five clinical variants are recently recognized as follows: classic(ulcerative), bullous, pustular, vegetative and peristomal types. Pyoderma gangrenosum is often a diagnosis of exclusion, as there are no specific laboratory or histopathologic findings to confirm the diagnosis. Accordingly, it is difficult to diagnose, and often requires a work-up for underlying systemic diseases. Mimickers include infection, vascular insufficiency, systemic vasculitides, autoimmune disease, skin cancer or exogenous tissue injury. Herein, we present two cases of ulcerative pyoderma gangrenosum occurring on the legs, along with a comprehensive review.
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